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. 2016 Jun 10;311(2):L375–L388. doi: 10.1152/ajplung.00132.2016

Fig. 8.

Fig. 8.

E2 enhances autophagic flux in the RV of acutely exercised rats. Effects are shown of sex, OVX, and E2 repletion on RV p62 accumulation (A) and RV LC3II-to-LC3I ratio (B). Note trend for increased p62 accumulation, as well as significant decrease in LC3II-to-LC3I ratio in female SuHx rats after OVX, with reversal of OVX effects on both parameters after E2 repletion. SuHx exposure, OVX, and E2 repletion were as outlined in Fig. 1. Values are means ± SE; N = 5–6/group. P < 0.01 vs. *female normoxia control, #female SuHx, and °female OVX SuHx (one-way ANOVA with post hoc Tukey's test). P = 0.06 for female OVX+E2 SuHx vs. female OVX SuHx in B.