APPENDIX E2.

Deyo–Charlson comorbidities by standard versus extended use of antibiotic prophylaxis

Comorbidities	Antibiotic prophylaxis				P value*
	Standard		Extended
	N	%	N	%
Deyo–Charlson comorbidity grouping
Myocardial infarction	46,017	37.6	12,416	38.3	.02
Congestive heart failure	23,970	19.6	6622	20.4	<.01
Peripheral vascular disease	18,933	15.5	4648	14.3	<.01
Cerebrovascular disease	11,696	9.6	3033	9.4	.27
Dementia	359	0.3	89	0.3	.57
Chronic pulmonary disease	30,157	24.6	7226	22.3	<.01
Rheumatologic disease	2331	1.9	619	1.9	.96
Peptic ulcer disease	1800	1.5	451	1.4	.28
Mild liver disease	1844	1.5	492	1.5	.89
Moderate/severe liver disease	202	0.2	55	0.2	.86
Diabetes	44,951	36.7	12,272	37.9	<.01
Diabetes with chronic complications	6857	5.6	1591	4.9	<.01
Hemiplegia or paraplegia	589	0.5	185	0.6	.04
Renal disease	15,156	12.4	3677	11.3	<.01
Any malignancy	2983	2.4	758	2.3	.30
Metastatic solid tumor	316	0.3	63	0.2	.04

^*Chi-square test.