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. 2016 Nov 28;22:4612–4622. doi: 10.12659/MSM.897702

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© Med Sci Monit, 2016

This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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Changes in MWT and MWD of rats at each time point. S group, sham-operation group; M group, morphine group; BM group, bone cancer pain morphine tolerance group; MWT, mechanical withdrawal threshold; MWD, mechanical withdrawal duration; T₀: pre-operative Day 1; T_1–3: Day 3, 6, and 9 post CIBP modeling; T_4–6: Day 3, 6 and 9 after intrathecally administering morphine. (A) The changes of MWT of rats at each time point in these 3 groups; (B) The changes of MWD of rats at each time point in these 3 groups. * Compared with S group, P<0.05; ^# compared with M group, P<0.05.