Table 2. Summary of immunophenotypic characterization of AITL by flow cytometry.
Antigen/pattern | Bone marrow (%) | Peripheral blood (%) | Lymph node (%) | Body fluid (%) |
---|---|---|---|---|
Surface CD3 (N = 97) | N = 41 | N = 16 | N = 31 | N = 9 |
Complete loss | 26 (63.4) | 13 (81.3) | 12 (38.7) | 2 (22.2) |
Partial loss | 1 (6.3) | 4 (12.9) | ||
↓intensity | 12 (29.3) | 2 (12.5) | 15 (48.4) | 4 (44.4) |
↑Intensity | 2 (4.9) | |||
TCRαβ (N = 80) | N = 39 | N = 12 | N = 22 | N = 8 |
Complete loss | 25 (64.1) | 10 (83.3) | 11 (50.0) | 2 (25.0) |
↓intensity | 1 (2.6) | 2 (16.7) | 5 (22.7) | |
CD10 (N = 85) | N = 36 | N = 14 | N = 27 | N = 8 |
CD10+ | 5 (13.9 %) | 4 (28.6) | 11 (40.7) | 5 (62.5) |
CD10+ (partial or subset) | 13 (36.1 %) | 5 (35.7) | 13 (48.1) | 2 (25) |
CD7 (N = 86) | N = 39 | N = 14 | N = 24 | N = 9 |
Complete loss | 16 (41.0) | 4 (28.6) | 9 (37.5) | 8 (88.9) |
Partial loss | 9 (23.1) | 1 (7.1) | 1 (4.2) | 1 (11.1) |
↓intensity | 2 (5.1) | 1 (4.2) | ||
↑Intensity | 1 | |||
CD4 (N = 97) | N = 41 | N = 16 | N = 31 | N = 9 |
↓intensity | 2 (4.9) | 4 (12.9) | 4 (44.4) | |
↑Intensity | 1 (3.2) | |||
CD52 (N = 81) | N = 38 | N = 13 | N = 22 | N = 8 |
Complete loss | 5 (13.2) | |||
↓intensity | 2 (9.1) | |||
CD5 (N = 89) | N = 40 | N = 15 | N = 26 | N = 8 |
Complete loss | 1 (2.5) | 1 (3.8) | ||
CD2 (N = 85) | N = 40 | N = 14 | N = 23 | N = 8 |
Complete loss | 1 (2.5) | |||
CD8 (N = 97) | N = 41 | N = 16 | N = 31 | N = 9 |
Partial expression (CD4+/CD8+) | 1 (2.4) |
A subset of specimens showed more than one immunophenotypic aberrancy in one (e.g., partial loss and decreased intensity) or more antigens.