. Author manuscript; available in PMC: 2016 Dec 7.

Published in final edited form as: J Trauma Acute Care Surg. 2015 Dec;79(6):905–910. doi: 10.1097/TA.0000000000000784

Table 1.

Selected laboratory Data

		Time points
Variables	Groups	Baseline	End of Hemorrhage
Weight (g)	Vehicle	248.90 ± 7.77	--
Weight (g)	Tubastatin A	272.70± 8.91	--
Total Blood Loss (ml)	Vehicle	8.63 ± 0.26	--
Total Blood Loss (ml)	Tubastatin A	9.42 ± 0.29	--
Cannulation Time (min)	Vehicle	29.80 ± 3.17	--
Cannulation Time (min)	Tubastatin A	34.50 ± 1.15	--
Hemoglobin (g/dL)	Vehicle	12.38 ± 0.36	8.92 ± 0.32^*
Hemoglobin (g/dL)	Tubastatin A	12.10 ± 0.43	9.25 ± 0.24^*
Lactate (mmol/L)	Vehicle	1.48 ± 0.20	6.82 ± 1.03^*
Lactate (mmol/L)	Tubastatin A	1.30 ± 0.08	5.78 ± 0.26^*
Base Excess (mmol/L)	Vehicle	−0.72 ± 1.36	−9.17 ± 1.38^*
Base Excess (mmol/L)	Tubastatin A	0.40 ± 0.24	−5.25 ± 1.38^*
BUN (mg/dL)	Vehicle	15.60 ± 0.93	19.00 ± 1.67^*
BUN (mg/dL)	Tubastatin A	16.00 ± 1.16	19.75 ± 1.32^*

Sham=no hemorrhage, no resuscitation; Vehicle = hemorrhage, treatment with 1ul/g DMSO ip; Tubastatin A = Tubastatin A 70 mg/kg in 1ul/g DMSO ip; Baseline = before start of hemorrhage; End of Shock= end of total blood loss (55%). Data presented as group means ± SEM.

P < 0.05 compared with baseline value of the same group.