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. Author manuscript; available in PMC: 2016 Dec 7.
Published in final edited form as: Clin Cancer Res. 2014 Jun 26;20(17):4540–4548. doi: 10.1158/1078-0432.CCR-13-3231

Table 1. Summary of 99 consecutive patient cases.

Failed initial DNA extraction 1
Adequate DNA 98
Pre-treatment sequencing
Pre-treatment clonal IGH (V-J) 91
Pre-treatment clonal IGH (D-J) only 1
Pre-treatment bi-allelic IGH 26*
Post-treatment MRD
HTS+/mpFC+ post-treatment MRD 23
HTS+/mpFC− post-treatment MRD 28
HTS−/mpFC− post-treatment MRD 40
8 additional mpFC–negative cases, triple-flow cytometry sorted for HTS
Evidence of clonal, pre-treatment IGH in sorted mature B-cell fraction 1
No evidence of clonal, pre-treatment IGH in sorted mature B-cell fraction in samples with adequate DNA 7
*

Adequate DNA was only available to test for IGH D-J rearrangements (and therefore bi-allelic samples) in 84 of the 98 cases. Samples with three or more highly expanded IGH sequences were also not considered bi-allelic.