Fig 7. IL-27 promotes CD4+IL-10+ development and impairs anti-MCMV TH1 immunity and control of MCMV persistence.
Il-27rα-/- or WT (C57BL/6) mice were infected with MCMV and spleen and salivary gland CD4+/IFNγ+ (A) responses were quantified and expressed as mean + SEM of 11 mice/group. (B) Replicating virus in salivary gland homogenates of Il-27rα-/- and WT mice is shown as individual mice + median. Data is representative of 2 experiments. (C) MCMV genomes in saliva were quantified by qPCR. Data is shown as mean ± SEM from 11 mice per group from 2 replicative experiments.