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. Author manuscript; available in PMC: 2017 Dec 6.
Published in final edited form as: Structure. 2016 Nov 3;24(12):2067–2079. doi: 10.1016/j.str.2016.09.012

Figure 3. The Dissection-of-Function Mutant AIF78 W196A Dimerizes Without CTC Formation or Aromatic Tunnel Activation.

Figure 3

(A) The dimeric W196A mutant crystal structure lacks C-loop density. FAD domain (gold), NADH domain (green), C-terminal domain (teal), β-hairpin and C-loop boundaries (red). See also Figure S4, Table S1.

(B) W196A FAD isoalloxazine ring (left) and NADH binding pocket (right) (color) overlaid with structures of wild-type monomer (light gray, PDB: 4BV6) and dimer (dark gray, PDB: 4BUR).

(C) W196A C-terminal aromatic tunnel (left) and the border region of the C-loop insertion (right) (color) overlaid with structures of wild-type monomer (light gray) and dimer (dark gray).