Extended Data Figure 1.

Catalytic mTor inhibitors can induce blastocyst pausing. a, Kaplan-Meier survival curves of blastocysts cultured with (a) two catalytic mTor inhibitors, RapaLink-1 and AZD2014, and (b) two allosteric mTor inhibitors, Rapamycin and Everolimus, at different concentrations. c, Kaplan-Meier survival curves of blastocysts cultured with all 5 mTor inhibitors used in this study. The concentrations yielding the best survival outcome are shown. d, Kaplan-Meier survival curves of blastocysts cultured with the Myc-inhibitor 10058-F4 at 55 μM, as in Scognamiglio et al.⁶. Dotted lines indicate the time of blastocyst flushing (E3.5).