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. 2016 Oct 20;23(12):846–856. doi: 10.1038/gt.2016.61

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Schematic representation of pHR'SIN-cPPT-SFFV-FXN-WPRE. The pHR'SIN-cPPT-SFFV-FXN-WPRE vector is self-inactivating (SIN) configuration with a WPRE and an internal spleen focus-forming virus promoter-driving FXN gene expression. VSV-G pseudotyped pHR'SIN-cPPT-SFFV-FXN-WPRE was generated by HEK293T cells to a titer of 1 × 10⁸TU ml⁻¹ for infecting FRDA fibroblasts.