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. 2016 Jun 2;7(6):e2247. doi: 10.1038/cddis.2016.138

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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ROS/JNK pathway mediate erianin-induced apoptosis and autophagy in OS cells. Cells were preincubated with SP600125 (30 μM) or NAC (5 mM) for 2 h and then treated with erianin for 24 h. (a) Cell viability was measured by CCK8 assay. (b) Cell apoptosis was evaluated by flow cytometry. Results are presented as mean±S.D. from three independent experiments. *P<0.05, significantly different compared with the control, SP600125-treated, and NAC-treated groups. (c and d) The expression of apoptosis-related proteins were measured by western blotting. (e) Representative micrographs of cells that shows GFP-LC3 localization. (f and g) The level of autophagy-related proteins were analyzed by western blotting