. 2016 Jun 2;7(6):e2244. doi: 10.1038/cddis.2016.150

Table 5. Examples of opposing functions of TG2 in the pancreas.

Pancreas	Reports	Possible causation	References
Promotive effect	Glucose-stimulated insulin release	Different functional activity of TG2	^{152, 153, 154, 158, 159}
	Insulin secretion induced by RA and Ca²⁺		^{155, 156}
No effect	Insulin secretion induced by either cAMP or the phorbol ester PMAIntraperitoneal glucose tolerance tests and insulin tolerance tests	Different functional activity of TG2Different background of TG2 knockout miceBroad biological effects of TG inhibitors	^{157, 160}