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. 2016 Jun 16;7(6):e2263. doi: 10.1038/cddis.2016.163

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Table summarizing the results of the immuno-histochemical analysis of APC and μ-protocadherin (MUCDHL) protein levels in 21 CRC samples; + and − indicate presence or absence of the analyzed protein, respectively. (b) Immuno-histochemical analysis of two representative CRC cases exhibiting a double positive (APC+/MUCDHL+) (CRC +/+) or a double negative (APC−/MUCDHL−) (CRC −/−) expression pattern. Positivity appears as a dark staining; cell nuclei were counterstained with hematoxylin