Figure 2.

CHOP deficiency increased Ang II-induced expression of inflammatory factors. (a) RNA Seq was performed in Ang II-infused WT and CHOP KO mouse hearts at day 1. Gene Ontology (GO) analysis of log10-transformed P-values from biological process of GO terms. (b) Upregulated genes were shown as heat map. (c) qRT-PCR validation for RNA-seq data. The mRNA levels of TNF-α, IL-6, IL-10, IL-4 S100a8/a9, CCL2 and CXCL1 in Ang II-infused WT and CHOP KO hearts at day 1. n=6 per group. *P<0.05 compared with the Sham group. ^#P<0.05 compared with the WT group. ^##P<0.01 compared with the WT group