Figure 5.

CHOP deficiency in bone marrow-derived cells promoted Ang II-induced cardiac injury. (a) Masson's trichrome and picrosirius red staining in Ang II-infused heart tissues from bone marrow chimeric mice at day 7 (scale bars, 100 μm). (b) Quantification of fibrotic areas in heart sections with Masson's trichrome staining (n=4 in each group). (c) The representative pictures and quantification of α-SMA in staining in Ang II-infused heart tissues from bone marrow chimeric mice at day 7 (scale bars, 100 μm; n=4 in each group). (d) Collagen I, collagen III and fibronectin mRNA levels in in Ang II-infused heart tissues from bone marrow chimeric mice at day 7 (n=4 in each group). *P<0.05 compared with BM^WT to WT. ^#P<0.05 compared with BM^WT to KO. ^##P<0.01 compared with BM^WT to KO