Figure 3.

Insulin secretory response to Ca²⁺ signaling and [Ca²⁺]_c transient amplitude in si-Jph3 islets. (a) Insulin secretory response to Ca²⁺ signaling in the presence of glucose, and (b) [Ca²⁺]_c transient amplitude in response to chemicals. n=3 mice per group, with the minimum 30 islets per mouse for insulin secretion. (c) Expression of Ca²⁺ releasing proteins of ER (n=3). (d and e) Co-immunoprecipitation showed JPH3 binds to RyR2 in mouse (n=5) and human (n=3) pancreatic tissues. Data are means±S.D. *P<0.05, **P< 0.01 versus si-Ctr. ^#P<0.05, ^##P<0.01 versus control in the same group