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Heterologous production of antimycins by S. coelicolor is FscRI dependent. (A) S. coelicolor M1146 strains challenged with C. albicans. Only M1146 harboring both cosmid 213 and pIJ10257-fscRI inhibits the growth of C. albicans compared to M1146 and M1146 harboring cosmid 213. (B) LC-HRESI-MS analysis of chemical extracts prepared from strains shown in panel A; the extracted ion chromatograms (M+H)+ for antimycins A1 to A4 are shown for each strain.
