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Cell non-autonomous regulation of the UPRmt. Mitochondrial perturbations within three C. elegans sensory neurons (ASK, AWA, AWC) causes activation of ATFS-1 and the UPRmt within these cell types and also within intestinal cells. Transmission of a signal between the sensory neurons requires an interneuron (AIA), the secreted neuropeptide FLP-2 as well as ATFS-1 within the intestinal cells. It is currently unclear how secreted FLP-2 affects intestinal ATFS-1.
