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. 2016 Nov 24;2016:1536047. doi: 10.1155/2016/1536047

Figure 1.

Figure 1

Ffar4 HET and KO mice are protected against obesity development on a high fat ω3-PUFA diet. Mice were scaled weekly from 6 weeks of age; experimental diets were initiated when mice were 11 weeks old. ((a)–(f)) Heterozygotes. ((g)–(l)) Knockouts. ((a) and (g)) Weight development, n = 6–8. ((b) and (h)) Lean mass from MR scans 32 weeks after diet initiation (43 weeks of age), n = 6–8. ((c) and (i)) Fat mass from MR scans 32 weeks after diet initiation, n = 6–8. ((d) and (j)) eWAT weights 36 weeks after diet initiation, n = 6–8. ((e) and (k)) Liver weights 36 weeks after diet initiation, n = 6–8. ((f) and (l)) Feed intake measured two times a week in single-housed mice till 32 weeks after diet initiation, n = 5–7. All data are presented as means ± SEM. Both HFDs are compared to the LFD. For (a), (f), (g), and (l) data were Ln-transformed and 2-way RM ANOVA with Bonferroni correction was performed. All data shown in bar graphs were Ln-transformed and subjected to 1-way ANOVA with Bonferroni correction. Only statistical significant differences are shown. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, and ∗∗∗∗ p < 0.0001.