Table 6.
Cox regression analysis of prognostic factors in pancreatic ductal adenocarcinoma patients with synchronous liver metastasis undergoing surgery
| Parameter | n | Median OS (95%CI) (mo) | Univariate analysis |
Multivariate analysis |
||
| P value | Hazard ratio | 95%CI | P value | |||
| Age, yr | ||||||
| ≤ 62 | 32 | 9.988 (5.215-14.760) | ||||
| > 62 | 37 | 4.534 (3.294-5.774) | 0.006 | 2.191 | 1.182-4.060 | 0.013 |
| Sex | ||||||
| Male | 47 | 5.388 (2.454-8.322) | ||||
| Female | 22 | 7.129 (5.820-8.439) | 0.428 | |||
| BMI, kg/m2 | ||||||
| < 18 | 6 | 4.008 (0.000-8.701) | 0.939 | |||
| 18-25 | 54 | 6.998 (5.147-8.849) | ||||
| > 25 | 9 | 7.721 (1.548-13.894) | 0.548 | |||
| Smoke | ||||||
| No | 50 | 7.031 (4.606-9.455) | ||||
| Yes | 19 | 5.979 (0.607-11.352) | 0.317 | |||
| ASA | ||||||
| I | 21 | 9.988 (3.524-16.452) | ||||
| II-III | 48 | 6.998 (3.803-10.193) | 0.273 | |||
| Primary tumor location | ||||||
| Head/neck | 53 | 6.998 (4.910-9.086) | ||||
| Body/tail | 16 | 7.129 (3.438-10.820) | 0.762 | |||
| CA19-9, U/mL | ||||||
| ≤ 400 | 40 | 7.984 (6.454-9.513) | ||||
| > 400 | 29 | 4.008 (2.832-5.185) | 0.042 | 1.398 | 0.773-2.527 | 0.267 |
| CA125, U/mL | ||||||
| ≤ 62 | 32 | 9.035 (7.052-11.017) | ||||
| > 62 | 37 | 4.008 (2.801-5.215) | 0.003 | 2.601 | 1.403-4.823 | 0.002 |
| CEA, U/mL | ||||||
| ≤ 5 | 42 | 7.721 (6.340-9.102) | ||||
| > 5 | 27 | 5.191 (1.847-8.535) | 0.320 | |||
| Fibrinogen, g/L | ||||||
| ≤ 4.0 | 50 | 7.129 (5.373-8.886) | ||||
| > 4.0 | 19 | 5.191 (2.575-7.807) | 0.533 | |||
| NLR | ||||||
| ≤ 5 | 59 | 7.031 (5.123-8.939) | ||||
| > 5 | 10 | 4.008 (0.000-9.812) | 0.495 | |||
| PLR | ||||||
| ≤ 150 | 36 | 7.031 (4.545-9.517) | ||||
| > 150 | 33 | 5.979 (3.287-8.672) | 0.851 | |||
| PNI | ||||||
| > 45 | 42 | 7.129 (6.237-8.022) | ||||
| ≤ 45 | 27 | 5.848 (3.396-8.300) | 0.890 | |||
| Platelet | ||||||
| ≤ 250 × 109/L | 53 | 6.998 (5.018-8.978) | ||||
| > 250 × 109/L | 16 | 7.097 (0.957-13.236) | 0.993 | |||
| Jaundice | ||||||
| No | 34 | 7.721 (4.540-10.901) | ||||
| Yes | 35 | 6.998 (3.593-10.403) | 0.446 | |||
| Biliary drainage | ||||||
| No | 45 | 7.129 (5.245-9.014) | ||||
| Yes | 24 | 5.027 (1.872-8.181) | 0.878 | |||
| Bilirubin, μmol/L | ||||||
| ≤ 50 | 58 | 6.998 (4.918-9.078) | ||||
| > 50 | 11 | 7.031 (1.408-12.651) | 0.448 | |||
| Albumin, g/L | ||||||
| > 35 | 42 | 7.097 (4.893-9.300) | ||||
| ≤ 35 | 27 | 5.027 (2.171-7.882) | 0.799 | |||
| Diabetes mellitus | ||||||
| No | 39 | 6.998 (4.177-9.819) | ||||
| Yes | 30 | 6.998 (4.424-9.572) | 0.300 | |||
| Pancreatitis | ||||||
| No | 42 | 5.979 (4.876-9.186) | ||||
| Yes | 27 | 6.998 (2.516-11.480) | 0.789 | |||