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. 2004 Aug 17;32(14):4411–4419. doi: 10.1093/nar/gkh775

Figure 5.

Figure 5

Antisense effects on P-glycoprotein expression in NIH 3T3 MDR cells. NIH 3T3 MDR cells were treated with Lipofectamine 2000 complexes of various oligonucleotides, and cell surface P-glycoprotein expression in the viable cells was evaluated as described in Materials and Methods. x-Axes represent fluorescence intensity and y-axes represent cell number. Panels (A, D and G), control (Lipofectamine 2000 only); (B) 9 nM HNA gapmer mismatched (GS1957); (C) 9 nM HNA gapmer (GS1956); (E) 9 nM phosphorothioate scrambled control (10 221); (F) 9 nM phosphorothioate (5995); (H) 9 nM 2′-O-ME gapmer scrambled (13 753) (I) 9 nM 2′-O-ME gapmer (13 758). The demarcations between the left and right boxes in the figures are set at one standard deviation below the mean of the untreated control.