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Effects of antisense oligonucleotides on Rhodamine 123 accumulation. NIH 3T3 MDR cells were treated with 9 nM of antisense oligonucleotides complexed with Lipofectamine 2000 as described. Closed bars, control oligonucleotides; open bars, oligonucleotides targeted to MDR1 gene. Values are Rhodamine 123 uptake increase, with the 100% level taken as that for untreated NIH3T3 MDR cells. Mean and standard errors of 3–6 determinations.
