Table 2. Regression analysis of reported telomere length related loci with relative telomere length (RTL) among pregnant women and newborn.
Locus [reference] | Chr. | Associated gene | Reported effect allelea | Alternative allele | Maternal genotype and RTLb |
Cord genotype and RTLb |
||||
---|---|---|---|---|---|---|---|---|---|---|
EAFc | β | P | EAF | β | P | |||||
rs1093659919 | 3q26.2 | TERC | T | C | 0.574 | −0.0119 | 0.041 | 0.566 | −0.0017 | 0.819 |
rs1112552919 | 2p16.2 | ACYP2 | C | A | 0.811 | 0.0019 | 0.792 | 0.825 | −0.0012 | 0.892 |
rs273610019 | 5p15.33 | TERT | T | G | 0.570 | −0.0110 | 0.046 | 0.594 | 0.0052 | 0.470 |
rs273610822 | 5p15.33 | TERT | G | A | 0.684 | −0.0080 | 0.176 | 0.722 | −0.0020 | 0.799 |
rs438728721 | 10q24.33 | OBFC1 | C | A | 0.840 | −0.0027 | 0.725 | 0.847 | −0.0010 | 0.920 |
rs75501719 | 20q13.33 | RTEL1 | A | G | 0.590 | −0.0017 | 0.779 | 0.573 | 0.0023 | 0.736 |
rs767599819 | 4q32.2 | NAF1 | A | G | 0.155 | −0.0054 | 0.493 | 0.159 | −0.0005 | 0.958 |
rs810576719 | 19p12 | ZNF208 | A | G | 0.711 | 0.0061 | 0.307 | 0.719 | −0.0002 | 0.978 |
aThe reported effect allele associated with short telomeres in populations of European descent.
bDerived from generalized linear models. The reference homozygotes, heterozygotes and effect homozygotes were encoded as 0, 1 and 2, respectively.
cEAF: Effective allele frequency.