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. 2016 Dec 8;6:38498. doi: 10.1038/srep38498

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Exosome-treated cells displayed upregulated expression of pro-apoptotic molecules and downregulated expression of anti-apoptotic BCL2. (b) hAMSC-CM-derived exosome inhibition of A2780 cell proliferation. hAMSCs release exosomes in CM, where exosomes function as carriers of MSC-secreted miRNAs. Upon internalization by cancer cells, miRNA is released by exosomes to target genes expressing different molecules associated with cancer proliferation, thereby disrupting cancer metastasis. The experiments were repeated at least three times.