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. 2016 Dec 8;6:38728. doi: 10.1038/srep38728

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Copyright © 2016, The Author(s)

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The results indicate that reduced MDA generation inhibits JNK phosphorylation (pathway 2); increased DJ-1 expression promotes the expression of glutathione S-transferase (Gstm2), which inhibits JNK phosphorylation (pathway 3) and ryanodine receptor (RyR2) activity; and inhibited RyR2 activity subsequently reduces the cytosolic calcium concentration (pathway 4), which is also influenced by the increased expression of Na⁺/K⁺-transporting ATPase (Atp1b1) (pathway 10). However, increased DJ-1 expression inhibits the activity of monoamine oxidase (Maoa) (pathway 5); decreased gelsolin (Gsn) expression promotes Bcl-2 expression (pathway 6); increased translationally controlled tumour protein (Tpt1) expression promotes p53 degradation (pathway 7); and increased nucleoside diphosphate kinase (Nme) (pathway 8) and phosphatidylethanolamine-binding protein (Pebp1) (pathway 9) expression promote Akt phosphorylation. Proteins in the rectangles were confirmed in this study. WB indicates the proteins that were further confirmed by Western blot analysis. Proteins coloured red and blue are up-regulated and down-regulated, respectively. The unboxed components were arranged according to published sources. GSH, glutathione; ETC, electron transport chain; GRK2, G-protein coupled receptor kinase; HNE, 4-hydroxynonenal; metMb, metmyoglobin; MPTP, mitochondrial permeability transition pore; NOS, nitric oxide synthase; PI3K, phosphoinositide 3-kinase; PUFA, polyunsaturated fatty acids.