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. 2016 Dec 8;6:38728. doi: 10.1038/srep38728

Figure 5. WE mitigates adverse LV remodelling after MI in the LI model.

Figure 5

(a) Design of long-term ischaemia-only (LI) experiments with a WE dose of 400 mg/kg/day. (b) Representative heart morphologies after 30 days of LI. (c) Ratio of apoptotic cells to total cells in the infarct area. (d) Relative levels of cleaved caspase-3. (e) Infarct size assessed through H&E staining. (f) Collagen content. (g) Average LV wall thickness. (h) Expansion index. (i) Representative sections showing demarcated cardiomyocytes (left) and cardiomyocyte cross-sectional area (right). Effect of 10 mg/kg/day enalapril supplementation at 7 days is shown as a striped line on bar graphs for comparative purposes (e–h) (see Supplementary Fig. S6 for more accurate data). *P < 0.05, **P < 0.01, ***P < 0.001 compared with the controls. The numbers inside bars indicate the number of animals per group.