Figure 2. Altered membrane currents in TMEM16A proteins with chimeric C-termini.

(A) Representative membrane currents in HEK-293 cells expressing wild type TMEM16A or C-TERM/C-TERM4 mutants. Each panel reports superimposed currents elicited at different membrane voltages (−100 to +100 mV range) and at the indicated intracellular free Ca²⁺ concentrations. (B) Current-voltage relationships summarizing the results of experiments as those shown in (A). Each point is the mean ± SEM of 9–12 experiments.