Table 1. Reports the positions of the aminoacids replaced in chimeric, truncated and double chimeric constructs.
| Chimeras | Residues of TMEM16A Replaced by Equivalent Domain of TMEM16B (aa) |
|---|---|
| C-TERM | 900–982 |
| C-TERM 1 | 907–944 |
| C-TERM 2 | 945–982 |
| C-TERM 3 | 907–944 (945X) |
| C-TERM 4 | 907–931 (932X) |
| C-TERM 5 | 907–926 (928X) |
| C-TERM 6 | 907–922 (923X) |
| C-TERM 7 | 913–926 (928X) |
| C-TERM 8 | 917–926 (928X) |
| Double Chimeras | |
| N-TERM + C-TERM 1 | 1–341 and 907–944 |
| TMD1-2 + C-TERM 1 | 347–380, 429–450 and 907–944 |
| TMD3-4 + C-TERM 1 | 511–543, 556–583 and 907–944 |
| TMD9-10 + C-TERM 1 | 779–816 and 879–944 |
| LOOP1 + C-TERM 1 | 450–511 and 907–944 |
Further details may be provided on request.