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. 2004 Aug 9;101(33):11929–11936. doi: 10.1073/pnas.0403799101

Scheme 1.

Scheme 1.

Insights into the synthetic efficiency of nature: total synthesis of trichodimerol (12) through a dimerization event based on a double Michael/ketalization sequence. A different pathway from 6 led to bisorbicillinol (13) and bisorbibutenolide (14).