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. Author manuscript; available in PMC: 2017 Oct 17.
Published in final edited form as: Chem Res Toxicol. 2016 Sep 13;29(10):1651–1661. doi: 10.1021/acs.chemrestox.6b00186

Figure 6.

Figure 6

Dose–response curves for MEHP vs DEHP (A) or MiNP vs DiNP (B) with CAR2 and PXR. Results represent a single transfection experiment with all treatments in quadruplicate. COS-1 cells were transfected with the pcDNA3.1-RXRα expression vector, CYP2B6-PBREM-XREM (CAR2) or 3A4-XREM (PXR) reporter, the pRL-CMV vector for normalization of transfection efficiency, and either CMV2-CAR2 or CMV2-PXR. All treatments were for 24 h. The luciferase values were normalized for transfection efficiency and then corrected for background (DMSO) activity. All values represent the mean (± S.D.).