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. Author manuscript; available in PMC: 2017 Oct 17.
Published in final edited form as: Chem Res Toxicol. 2016 Sep 13;29(10):1651–1661. doi: 10.1021/acs.chemrestox.6b00186

Table 4.

EC50 Values (μM) and Maximum Activation of hCAR2 and hPXR by DEHP, DiNP, and Their Metabolites MEHP and MiNP

hCAR2 hPXR
EC50 95% CI max fold activation R2 EC50 95% CI max fold activation R2
MEHP 2.3 0.8–6.5 6.8 0.91 27.0 8.5–85.7 10.4 0.83
DEHP 0.1 0.05–0.18 7.1 0.94 3.5 1.2–10.1 13.7 0.89
MiNP 2.3 1.22–4.46 4.6 0.95 14.0 4.8–40.6 18.3 0.84
DiNP 0.7 0.35–1.22 4.2 0.95 29.5 5.0–172.8 7.8 0.68