Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Synthesis of the (7S)-epimer of the revised C5–C16 degradation fragment. Conditions: a, (i) 45, (-)-Ipc2BCl, Et3N, -78°C, Et2O; (ii) 48; b, diethylphosphonoacetic acid, DMAP, Et3N, 2,4,6-trichlorobenzoyl chloride, CH2Cl2, 0°C; c, Ba(OH)2, THF, 0°C; d, O3, MeOH, -78°C; NaBH4, -78°C to rt. †, 500 MHz, CD3OD, δ (ppm). ‡, Isolated as 1:2 mixture of (5S)-54a/(5R)-54b.
