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. 2016 Dec 8;9:95. doi: 10.1186/s13041-016-0277-4

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Perturbed hypothalamic neurochemistry in PWS-IC mice. In situ hybridisation analysis of ARC Pomc, Agrp, Npy and Bdnf mRNA expression in PWS-IC mice demonstrates a significant decrease in ARC Pomc mRNA expression, but no effect on ARC Agrp, Npy and Bdnf mRNA levels. Data presented as Mean ± SEM. Student’s t-test, *p < 0.05, **p < 0.01, **p < 0.001 compared to WT controls