Table 2.
Preoperative CEA level according to patients characteristics and time period
| CEA, median |
||||
|---|---|---|---|---|
| 2000–2007 (n = 216) | P | 2008–2015 (n = 268) | P | |
| Patient characteristics | ||||
| Gender | ||||
| Male | 7 | 0.906 | 7.6 | 0.488 |
| Female | 7.1 | 8.4 | ||
| Age, years | ||||
| > 55 | 7.3 | 0.366 | 7.7 | 0.335 |
| ≤ 55 | 7.0 | 7.6 | ||
| Primary tumor characteristics | ||||
| Tumor site | ||||
| Right | 7.4 | 0.816 | 7 | 0.637 |
| Left | 7 | 7.8 | ||
| T stage (n = 441) | ||||
| T1 or T2 stage | 9.6 | 0.297 | 7.6 | 0.639 |
| T3 or T4 stage | 7 | 8.8 | ||
| Nodal metastases | ||||
| Positive | 7 | 0.992 | 7.5 | 0.234 |
| Negative | 7.1 | 8.5 | ||
| Preoperative factors | ||||
| Prior history of chemotherapy | ||||
| Yes | 7 | 0.480 | 7.7 | 0.562 |
| No | 8.6 | 7.6 | ||
| -Modern cytotoxic regimen | ||||
| Yes | 5.8 | 0.009 | 7.6 | 0.901 |
| No | 10.5 | 8.2 | ||
| -Biological agent | ||||
| Yes | 5 | 0.420 | 9.0 | 0.145 |
| No | 7.4 | 7.1 | ||
| CRC at hepatectomy | ||||
| Present | 14.0 | 0.202 | 7.8 | 0.741 |
| Resected | 7.0 | 7.6 | ||
| CRLM characteristics | ||||
| No. of CRLM | ||||
| >2 | 6.4 | 0.840 | 7.4 | 0.060 |
| ≤2 | 7.5 | 10.1 | ||
| Size of largest CRLM, cm | ||||
| >3 | 11.1 | <0.001 | 12.1 | <0.001 |
| ≤3 | 5.0 | 6.8 | ||
| Bilateral disease | ||||
| Positive | 7.1 | 0.770 | 7.6 | 0.522 |
| Negative | 6.3 | 7.4 | ||
| K-ras mutation status (n = 402) | ||||
| Wild-type | 6.4 | 0.624 | 10.5 | 0.110 |
| Mutated | 7.5 | 7.0 | ||
CEA, carcinoembryonic antigen; CRC, colorectal cancer; CRLM, colorectal liver metastases.
Statistical significant values are indicted in bold italics.