Table 3.
Glutathione species of healthy subjects and patients with ESLD stratified by disease process categories: metabolic (NASH), toxic (alcohol related), infectious (HCV, HBV), cholestatic (autoimmune, PSC, PBC) and other (SBC, chronic rejection)
| Healthy | ESLD |
p-Value* | |||||
|---|---|---|---|---|---|---|---|
| Metab | Toxic | Infec | Choles | Other | |||
| Subjects (n) | 20 | 5 | 4 | 35 | 2 | 8 | |
| MELD | 4.3 ± 1.2 | 14 ± 5.3 | 17 ± 27.5 | 11.7 ± 4.8 | 11 ± 2.8 | 10.1 ± 2.3 | <0.05 |
| Child-Pugh | 5.0 ± 0.0 | 7.6 ± 2.3 | 8.5 ± 2.4 | 6.8 ± 1.5 | 6 ± 0 | 5.6 ± 0.7 | <0.05 |
| Encephalopathy (seconds) | 12.3 ± 5.2 | 13.8 ± 3.7 | 9.6 ± 2.7 | 16.7 ± 8.2 | 20.5 ± 12 | 29.2 ± 23 | <0.05 |
| GSH (nMol/ml) | 3.9 ± 1.6 | 2.5 ± 1.3 | 2.4 ± 1.2 | 3.5 ± 4.8 | 2.8 ± 0.5 | 2.6 ± 1.4 | |
| GSSG-bound | 3.6 ± 1.4 | 1.9 ± 1.0 | 1.8 ± 0.9 | 2.6 ± 2.8 | 1.5 ± 0.4 | 2.0 ± 0.8 | <0.05 |
| OA | 4.0 ± 4 | 6.4 ± 4.7 | 5.9 ± 3.1 | 8.9 ± 4.6 | 5.7 ± 4.4 | 4.9 ± 4.5 | <0.05 |
*p < 0.05 by t-test when compared to healthy controls.