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. 2016 Dec 8;3(6):ENEURO.0108-16.2016. doi: 10.1523/ENEURO.0108-16.2016

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Copyright © 2016 Khanday et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 5. — Changes in REMS frequency per hour (top) and REMS duration/episode (s; bottom) during the recording of TH-shRNA or Ctrl-shRNA 8 d after microinjection into LC and Sal or NA microinjection into PPT (on the recording day), and 21 d after TH-shRNA microinjection. a–d, The histograms show analyses for the total recording period of 12 h (10:00 A.M. to 10:00 P.M.; a, c), and 8 h (10:00 A.M. to 6:00 P.M.) and 4 h (6:00 to 10:00 P.M.; b, d). Abbreviations are as in the text. *Compared with baseline and Ctrl-shRNA; $compared with TH-shRNA injection into LC and NA injection into PPT or 3 weeks after the injection of TH-shRNA into the LC. Significance level: ***p < 0.001; **p < 0.01;*p < 0.05; N = 6.