Table 2.
Species Distribution and Susceptibility Profile of Nocardia Isolates
| Species | No. of Isolates (%Total) | No. of Isolates With AST | Percentage (Proportion) of Isolates Susceptible | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| LZD | TMP-SMX | AMK | CEF | CLA | IMI | CIP | AUG | |||
| Nocardia asteroides sensu stricto | 7 (11%) | 7 | NP | 100% (7/7) | 100% (5/5)* | 100% (7/7) | 33% (1/3)* | 86% (6/7) | 29% (2/7) | 0% (0/7) |
| N asteroides complex† | 9 (14%) | 9 | 100% (3/3)* | 89% (8/9) | 89% (8/9) | 67% (6/9) | 78% (7/9) | 67% (6/9) | 33% (3/9) | 33% (3/9) |
| Nocardia beijingensis | 4 (6%) | 4 | 100% (3/3)* | 100% (4/4) | 100% (4/4) | 100% (4/4) | 100% (3/3)* | 50% (2/4) | 25% (1/4) | 0% (0/4) |
| Nocardia blacklockiae | 1 (2%) | 1 | 100% (1/1) | 100% (1/1) | 0% (0/1) | 100% (1/1) | 100% (1/1) | 0% (0/1) | 0% (0/1) | 0% (0/1) |
| Nocardia brevicatena | 1 (2%) | 1 | 100% (1/1) | 100% (1/1) | 100% (1/1) | 100% (1/1) | 100% (1/1) | 0% (0/1) | 100% (1/1) | 0% (0/1) |
| Nocardia caviae | 3 (5%) | 1 | NP | 100% (1/1) | 100% (1/1) | 0% (0/1) | 0% (0/1) | 100% (1/1) | 0% (0/1) | 0% (0/1) |
| Nocardia cyriacigeorgica | 7 (11%) | 6 | 100% (4/4)* | 67% (4/6) | 100% (6/6) | 67% (4/6) | 0% (0/6) | 33% (2/6) | 0% (0/6) | 0% (0/6) |
| Nocardia cerradoensis | 1 (2%) | 0 | NP | NP | NP | NP | NP | NP | NP | NP |
| Nocardia elegans | 1 (2%) | 1 | 100% (1/1) | 100% (1/1) | 100% (1/1) | 0% (0/1) | NP | 0% (0/1) | NP | NP |
| Nocardia farcinica | 3 (5%) | 2 | 100% (1/1)* | 100% (1/1)* | 100% (2/2) | 0% (1/1)* | 0% (1/1)* | 0% (0/1)* | 100% (2/2) | 0% (0/1)* |
| Nocardia nova | 2 (3%) | 1 | NP | 100% (1/1) | 100% (1/1) | NP | 100% (1/1) | 100% (1/1) | 0% (0/1) | 0% (0/1) |
| Nocardia otidiscaviarum | 3 (5%) | 3 | NP | 100% (3/3) | 100% (2/2)* | 0% (0/3) | 0% (0/2)* | 33% (1/3) | 33% (1/3) | 0% (0/3) |
| Nocardia pseudobrasiliensis | 2 (3%) | 2 | NP | 100% (2/2) | 50% (1/2) | 100% (2/2) | 100% (2/2) | 0% (0/2) | 100% (2/2) | 0% (0/2) |
| Nocardia seriolae | 1 (2%) | 1 | NP | 100% (1/1) | 100% (1/1) | 0% (0/1) | 100% (1/1) | 0% (0/1) | 0% (0/1) | 0% (0/1) |
| Nocardia transvalensis | 2 (3%) | 2 | 100% (1/1)* | 50% (1/2) | 0% (0/2) | 100% (2/2) | 0% (0/2) | 0% (0/2) | 50% (1/2) | 0% (0/2) |
| Nocardia veterana | 3 (5%) | 3 | NP | 100% (3/3) | 100% (3/3) | 67% (2/3) | 67% (2/3) | 67% (2/3) | 0% (0/2)* | 0% (0/3) |
| Nocardia sp (unspeciated) | 13 (21%) | 11 | 100% (7/7)* | 82% (9/11) | 91% (10/11) | 27% (3/11) | 60% (6/10)* | 45% (5/11) | 27% (3/11) | 10% (1/10)* |
| Total (all Nocardia isolates) | 63 | 55 | 22/22 (100%) | 48/54 (89%) | 46/52 (89%) | 32/53 (60%) | 25/46 (55%) | 26/54 (48%) | 16/53 (30%) | 4/52 (8%) |
Abbreviations: AMK, amikacin; AST, antimicrobial susceptibility testing; AUG, amoxicillin-clavulanate; CEF, ceftriaxone/cefotaxime; CIP, ciprofloxacin; CLA, clarithromycin; IMI, imipenem/meropenem; LZD, linezolid; NP, testing not performed; TMP-SMX, trimethoprim-sulfamethoxazole.
*Indicates that 1 or more isolates were not tested.
†The “N asteroides complex” is an old taxonomic classification referring to a group of Nocardia isolates that have now been separated into different species (including N nova, N transvalensis, and N farcinica).