Fig. 1.

Effects of recombinant IL-37 treatment on streptococcal cell wall-induced arthritis

(A) Representative photographs of joints of a normal knee and from vehicle- and IL-37-treated mice (see Methods section). (B) Mean (s.e.m.) of joint scores. (C and D) Microphotographs of representative knee joint sections from vehicle- (C) and IL-37-treated mice (D); original magnification 100×. (E) Mean (s.e.m.) of synovial cell influx. Student’s unpaired t-test was used for statistical analyses; data are expressed as the mean (s.e.m.) of 10 knee joints per group; ***P < 0.001.