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. 2004 Aug 4;101(33):12300–12305. doi: 10.1073/pnas.0404764101

Fig. 3.

Fig. 3.

Prevention of up-regulation of UPR genes by chemical chaperones. COS-7 cells transfected with wild-type CA IV (WT) or R14W CA IV (MT) cDNA were incubated with normal medium (–), 10 μM acetazolamide (AC), or 2 mM PBA for 72 h after transfection. The results were quantitated by counting the cells positive for BiP (A), PERK (B), and CHOP (C) from three to five fields. The results indicate that up-regulation of the UPR genes in COS-7 cells expressing R14W CA IV was greatly reduced (but not totally prevented) by chemical chaperones.