Fig. 2.
Mefloquine reduces junctional currents from N2A cells expressing Cx36, Cx50, and Cx43 in a concentration-dependent and connexin-selective manner. (A) Mefloquine decreased Ij of Cx36 in a concentration-dependent but irreversible manner. Recordings in A are from two separate cell pairs. (B) Cx50 channels were almost completely blocked by 3 μMmefloquine. (C) Higher concentration was required to elicit closure of Cx43 channels. (D) Concentration dependence of mefloquine on Cx36 (○) and Cx50 (•). Each point represents the mean of four to ten cell pairs. Each cell pair was exposed to only a single concentration. (E) Effect of 10 and 30 μMmefloquine on Cx26, Cx32, Cx36, Cx43, Cx46, and Cx50. Each bar represents the mean of four to six cell pairs.