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. 2004 Aug 24;2(9):e296. doi: 10.1371/journal.pbio.0020296

Figure 2. Life Span Extension by CR Does Not Require Sir2.

Figure 2

(A) CR fails to increase life span of a sir2Δ mutant. Strains shown (and mean life span) are BY4742 (26.7), sir2Δ (14.0), hxk2Δ sir2Δ (12.4), and gpa2Δ sir2Δ (11.7).

(B) Deletion of FOB1 suppresses the short life span of a sir2Δ strain. Strains shown and mean life spans are: BY4742 (27.5), sir2Δ (14.0), sir2Δ fob1Δ (30.0).

(C) Deletion of HXK2 increases the life span of a sir2Δ fob1Δ double mutant. Strains shown (and mean life spans) are BY4742 (26.5), sir2Δ fob1Δ (30.0), and sir2Δ fob1Δ hxk2Δ (45.3).

(D) Deletion of GPA2 increases the life span of a sir2Δ fob1Δ double mutant. Strains shown (and mean life spans) are BY4742 (26.6), sir2Δ fob1Δ (30.0), and sir2Δ fob1Δ gpa2Δ (51.0).