Table 2. FOB1 Deletion or SIR2 Overexpression Increase Life Span in Multiple Genetic Backgrounds.

The percent effect on mean RLS ((mutant − wild-type)/wild-type × 100) as a result of FOB1 deletion or SIR2 overexpression is shown for each strain relative to the parental wild-type (strain background). The reported mean RLS for fob1Δ and SIR2-overexpressing mutants in each strain is also shown in parentheses. To our knowledge, PSY316 is the only background in which these interventions do not increase longevity