Figure 4.
Frequencies of mitochondrial (A) and Y-chromosome (B) haplogroups by generation. Size of points indicates the number of mice sampled per generation; ribbons indicate 95% binomial C.I. for the estimated frequencies. Strains A/J, C57BL/6J, 129S1/SvImJ, and NOD/ShiLtJ (“ABCD”) share the same mitochondrial haplogroup; strains C57BL/6J, 129S1/SvImJ, and NZO/HlLtJ (“BCE”) have Y-chromosome haplogroups indistinguishable with current genotyping arrays. Input frequencies are based on the breeding structure of the CC lines used to establish the DO population. DO, Diversity Outbred.