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. Author manuscript; available in PMC: 2016 Dec 8.
Published in final edited form as: Science. 2016 Jun 10;352(6291):aad9926. doi: 10.1126/science.aad9926

Fig. 4. Regulated or misregulated Pol II termination.

Fig. 4

(A) Primary piRNA clusters in Drosophila are often positioned between convergent genes. dsRNA induces heterochromatic histone tail modification (H3K9me3). This in turn recruits the HP1-like factor Rhino together with Cutoff, an anti-terminator that promotes readthrough transcription. (B) Inactivation of termination by cancer mutation (SETD2 mutation), osmotic stress, or viral infection all induce Pol II read-through and interference with downstream gene expression.