Table 2.
Pin1 ablation does not affect the development of virgin mammary glands
Genotypes | Primary ducts | Secondary ducts | Tips |
---|---|---|---|
MMTV-Neu/Pin1+/+ | 7.0±0.7 | 27.5±3.5 | 162.5±33.0 |
MMTV-Neu/Pin1−/− | 7.3±1.5 | 31.0±7.6 | 160.5±11.7 |
MMTV-Ras/Pin1+/+ | 7.2±1.5 | 31.0±4.1 | 160.5±16.3 |
MMTV-Ras/Pin1−/− | 6.7±1.5 | 30.3±8.5 | 149.3±28.6 |
Virgin mammary glands from MMTV-Neu or -Ras transgenic mice in Pin1+/+ or Pin1−/− genetic background were stained with carmine red and whole mounts were prepared. Primary ducts, secondary branches and tips and end buds were counted in a representative frame under a dissecting microscope. Three to five animals were analyzed in each cohort. |