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Model for the regulation of Cdc25 phosphatases by Chk1 and Chk2. In response to genotoxic stress, both Chk1 and Chk2 phosphorylate various Cdc25 phosphatases on multiple N-terminal sites (N-℗) and inhibit them by various mechanisms; however, only Chk1 phosphorylates the various phosphatases on a C-terminal site (C-℗) and inhibits them from C-terminally interacting with their Cdk–cyclin substrates. Chk1 also functions during an unperturbed cell cycle. See text for details.
