Table 3.

Ranking of Protein Pathways¹

Rank	Pathway	Number of proteins in pathway
1	Complement cascade	24
2	Immune System	222
3	Formation of Fibrin Clot (Clotting Cascade)	21
4	Metabolism of proteins	33
5	Signal Transduction	236
6	Post-translational protein modification	15
7	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation	12
8	Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)	17
9	Innate Immune System	120
10	Diabetes pathways	25
11	Integrin cell surface interactions	25
12	Hemostasis	119
13	Transcriptional Regulation of White Adipocyte Differentiation	5
14	Signaling by NOTCH	16
15	Signaling by NOTCH3	5
16	Integrin alpha IIb beta3 signaling	12
17	Activation of Genes by ATF4	3
18	Disease	137
19	Platelet Aggregation (Plug Formation)	16
20	Prolactin receptor signaling	6
21	Signaling by NOTCH1	14
22	Cytokine Signaling in Immune system	64
23	Growth hormone receptor signaling	10
24	Cell surface interactions at the vascular wall	38
25	Amyloids	13

¹Top 25 ranked pathways. The proteins were classified into known pathways using Reactome, these pathways can overlap with each other and are hierarchical (i.e., one pathway could be a subset of another pathway). The ranking of each pathway was determined by combining the individual p-values from the logistic regression for the proteins in the pathway.