Table 3.

Additional genes related to apoptosis and the Major Histocompatibility Complex shown to be up-regulated in MSI-H colorectal cancer in comparison to MSS cancers.

Apoptosis related genes up-regulated in MSI-H colorectal cancers (P < 0.005, Benjamini and Hochberg False Discovery Rate)
Gene name	Fold change
TNF-induced protein	1.9
Tumour necrosis factor receptor superfamily 10d	1.9
Tumour necrosis factor receptor superfamily 9	1.7
Tumour necrosis factor receptor superfamily 10b	1.7
Tumour necrosis factor receptor superfamily 6	1.6
Death-associated protein kinase 1	1.5
DNA fragmentation factor, beta polypeptide (caspase-activated DNase)	1.4
Bcl-2-related protein A1	2.2
Bcl-2/adenovirus E1B 19 kDa interacting protein 3-like	1.8
Bcl-2 antagonist/killer	1.4
Bcl-2 associated athanogene 3	1.4
Bcl-2/adenovirus E1B 19 kDa interacting protein 1	1.2
Baculoviral IAP repeat-containing 3	1.6
Baculoviral IAP repeat-containing 2	1.2
Chemokine (C-X-C motif) receptor 4	1.8
CD27-binding (Siva) protein	1.5
Thioredoxin-like, 32 kDa	1.4
Mitogen-activated protein kinase kinase kinase 5	1.4
Microtubule associated protein tau	1.4
Macrophage erythroblast attacher	1.3
Testis enhanced gene transcript (BAX inhibitor 1)	1.2
Major histocompatibility complex-related genes up-regulated in MSI-H colorectal cancer (P < 0.05, Benjamini and Hochberg False Discovery Rate)
Gene name	Fold change
Major histocompatibility complex, class II, DR alpha	2.0
Major histocompatibility complex, class II, DQ beta 1	1.8
Major histocompatibility complex, class II, DP alpha 1	1.8
H. sapiens HLA-DMA gene	1.7
Major histocompatibility complex, class II, DR beta 1	1.6
Major histocompatibility complex, class II, DR beta 5	1.5
HLA-B associated transcript 1	1.2
Major histocompatibility complex, class I, C	1.2