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Aβ42 and tau-PS262 dynamics. (a) Aβ42 and tau-PS262 levels were monitored in the same SH-SY5Y-tau cell when no isoflurane was applied (control condition). (b) Aβ42 and tau-PS262 levels were monitored after the treatment of isoflurane in the SH-SY5Y-tau cell up to 16 h. (c, d) Dynamic Aβ42 and tau-PS262 levels in SH-SY5Y-tau cells, which were preconditioned with 0.5 μM γ-secretase inhibitor (c) or 3 μM phosphorylation kinase inhibitor K252a (d) prior to the isoflurane treatment.
