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. 2004 Aug 24;2(10):e288. doi: 10.1371/journal.pbio.0020288

Figure 5. Oxidative Metabolism and Serum Lactate Production in HIF-1α KOs and WT Mice.

Figure 5

(A) HIF-1α KOs have higher resting levels of CS activity. CS is an enzyme in the Krebs cycle that can be regulated allosterically by ATP levels. Increased CS activity is indicative of increased muscle oxidative capacity, which is common in patients with glycogenolytic or glycolytic myopathies (# p < 0.10, KO vs. WT).

(B) HIF-1α KOs have higher resting levels of B-HAD activity, which is indicative of a greater ability to oxidize fatty acids (**p < 0.01, WT vs. KO).

(C) Lower serum lactate levels were seen in HIF-1α KOs following a timed 25-minute run (*p < 0.05, WT vs. KO).